Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1610692 | 0.81 | TAAR1 (0.31) | — | |
| SCHEMBL1287616 | 0.80 | TYR (0.39) | HTTHPGDNPC1MAPK1RAB9A | |
| SCHEMBL4803729 | 0.79 | HTT (0.50) | HTTHPGDNPC1MAPK1RAB9A | |
| SCHEMBL30568741 | 0.79 | HTT (0.47) | HTTHPGDNPC1MAPK1RAB9A | |
| SCHEMBL13890665 | 0.79 | NOS2 (0.46) | HTTHPGDNPC1MAPK1RAB9A | |
| SCHEMBL1610234 | 0.79 | TAAR1 (0.31) | — | |
| SCHEMBL549360 | 0.79 | HTT (0.47) | HTTHPGDNPC1MAPK1RAB9A | |
| SCHEMBL1609292 | 0.78 | MAPT (0.32) | MAPTSMN1; SMN2 | |
| SCHEMBL1611563 | 0.78 | MAPT (0.32) | MAPTSMN1; SMN2 | |
| SCHEMBL1610544 | 0.78 | MAPT (0.32) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917217-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S A (PL) | 2017-03-08 | — | — | EP | disclosed |