Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 5/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99492 | 0.80 | PRKCI (0.43) | PRKCIAKT2AXLNUDT1JAK3 | |
| SCHEMBL13774669 | 0.78 | PRKCI (0.52) | PRKCIAKT2AXLNUDT1JAK3 | |
| SCHEMBL10179493 | 0.78 | PRKCI (0.42) | PRKCIAKT2NUDT1JAK3PBK | |
| SCHEMBL100042 | 0.77 | GRM5 (0.57) | PRKCINUDT1JAK3JAK2PRKACA | |
| SCHEMBL29540469 | 0.75 | PRKCI (0.55) | PRKCIAKT2AXLNUDT1JAK3 | |
| SCHEMBL101819 | 0.75 | PRKCI (0.55) | PRKCIAKT2AXLNUDT1JAK3 | |
| SCHEMBL29540619 | 0.74 | JAK2 (0.52) | PRKCIAKT2NUDT1JAK3CCNK | |
| SCHEMBL100939 | 0.74 | JAK2 (0.52) | PRKCIAKT2NUDT1JAK3CCNK | |
| SCHEMBL18599530 | 0.74 | PRKCI (0.38) | PRKCIAKT2AXLNUDT1JAK3 | |
| SCHEMBL19062267 | 0.72 | PRKCI (0.37) | PRKCIAKT2NUDT1JAK3PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |
| EP-2343299-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |