Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.35 |
| ▸ | AKT2 | P31751 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18599530 | 0.80 | PRKCI (0.38) | PRKCINUDT1AKT2JAK3PBK | |
| SCHEMBL99492 | 0.73 | PRKCI (0.43) | PRKCINUDT1AKT2JAK3PBK | |
| SCHEMBL18602143 | 0.72 | PRKCI (0.49) | PRKCINUDT1AKT2JAK3PBK | |
| SCHEMBL10179493 | 0.72 | PRKCI (0.42) | PRKCINUDT1AKT2JAK3PBK | |
| SCHEMBL22930858 | 0.71 | PRKCI (0.39) | PRKCINUDT1AKT2JAK3PBK | |
| SCHEMBL100939 | 0.69 | JAK2 (0.52) | PRKCINUDT1AKT2JAK3AURKB | |
| SCHEMBL29540619 | 0.69 | JAK2 (0.52) | PRKCINUDT1AKT2JAK3AURKB | |
| Trifluoroacetic Acid SCHEMBL4081895 | 0.68 | JAK3 (0.37) | PRKCIAKT2JAK3PBKAURKA | |
| SCHEMBL102456 | 0.67 | PRKCI (0.46) | PRKCINUDT1AKT2JAK3PBK | |
| SCHEMBL29540558 | 0.67 | MAPK14 (0.48) | PRKCINUDT1AKT2JAK3PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-3838903-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |
| EP-3466953-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |