Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871722 | 0.95 | ALDH1A1 (0.56) | ALDH1A1TSHRDNM1CHRM2TDP1 | |
| SCHEMBL17891279 | 0.89 | ALDH1A1 (0.73) | ALDH1A1TSHRDNM1TDP1CA12 | |
| SCHEMBL13914579 | 0.89 | ALDH1A1 (0.73) | ALDH1A1TSHRDNM1TDP1CA12 | |
| SCHEMBL8624961 | 0.89 | ALDH1A1 (0.73) | ALDH1A1TSHRDNM1TDP1CA12 | |
| SCHEMBL29084940 | 0.89 | ALDH1A1 (0.73) | ALDH1A1TSHRDNM1TDP1CA12 | |
| SCHEMBL7008290 | 0.89 | — | — | |
| SCHEMBL22946813 | 0.86 | ALDH1A1 (0.79) | ALDH1A1TSHRDNM1CHRM2TDP1 | |
| SCHEMBL11862445 | 0.86 | ALDH1A1 (0.79) | ALDH1A1TSHRDNM1CHRM2TDP1 | |
| SCHEMBL14270551 | 0.86 | ALDH1A1 (0.79) | ALDH1A1TSHRDNM1CHRM2TDP1 | |
| SCHEMBL10903571 | 0.86 | ALDH1A1 (0.79) | ALDH1A1TSHRDNM1CHRM2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10465303-B2 | Producing system of reduction product | KABUSHIKI KAISHA TOSHIBA (JP) | 2019-11-05 | — | — | US | disclosed |
| US-20170073827-A1 | PRODUCING SYSTEM OF REDUCTION PRODUCT | KABUSHIKI KAISHA TOSHIBA (JP) | 2017-03-16 | — | — | US | disclosed |