Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173108 | 0.84 | HSD11B1 (0.53) | HSD11B1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL14897752 | 0.83 | HSD11B1 (0.48) | HSD11B1KDM1AHDAC8HDAC6HDAC3 | |
| SCHEMBL895157 | 0.81 | HSD11B1 (0.53) | HSD11B1KDM1AHDAC8HDAC6HDAC3 | |
| SCHEMBL1957769 | 0.81 | HSD11B1 (0.45) | HSD11B1KDM1AHDAC8HDAC6HDAC3 | |
| SCHEMBL17965902 | 0.81 | HSD11B1 (0.45) | HSD11B1KDM1AHDAC8HDAC6HDAC3 | |
| SCHEMBL9618427 | 0.79 | HSD11B1 (0.49) | HSD11B1KDM1AHDAC8HDAC6HDAC3 | |
| SCHEMBL14675152 | 0.78 | HSD11B1 (0.53) | HSD11B1KDM1AHDAC8HDAC6HDAC3 | |
| SCHEMBL14675151 | 0.78 | HSD11B1 (0.53) | HSD11B1KDM1AHDAC8HDAC6HDAC3 | |
| SCHEMBL17965904 | 0.78 | HSD11B1 (0.54) | HSD11B1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL2402582 | 0.78 | HSD11B1 (0.51) | HSD11B1HDAC3HDAC1HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935824-B2 | Ethylenediamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-03 | — | — | US | disclosed |