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Sugi Predict / Compounds / 5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine

5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine

5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine

SCHEMBL18608035

C[C@@H]1CN(C2CCN(c3nnc(N)[nH]3)CC2)C(Cc2ccc(Cl)cc2)CO1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CHIT1 Q13231 17/20 0.69
▸ CHIA Q9BZP6 17/20 0.69
▸ KCNH2 Q12809 13/20 0.69
▸ CHI3L1 P36222 9/20 0.65
▸ CHI3L2 Q15782 3/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine SCHEMBL18610037 1.00 CHIT1 (0.69) CHIT1CHIAKCNH2CHI3L1CHI3L2
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine SCHEMBL18609981 1.00 CHIT1 (0.69) CHIT1CHIAKCNH2CHI3L1CHI3L2
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine SCHEMBL18577134 1.00 CHIT1 (0.69) CHIT1CHIAKCNH2CHI3L1CHI3L2
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine SCHEMBL18577106 1.00 CHIT1 (0.69) CHIT1CHIAKCNH2CHI3L1CHI3L2
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine SCHEMBL18577306 1.00 CHIT1 (0.69) CHIT1CHIAKCNH2CHI3L1CHI3L2
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-Methylmorpholino)Piperidin-1-Yl)-1H-1,2,4-Triazol-3-Amine SCHEMBL29518374 0.99 CHIT1 (0.68) CHIT1CHIAKCNH2CHI3L1CHI3L2
SCHEMBL22901909 0.91 KCNH2 (0.70) CHIT1CHIAKCNH2CHI3L1CHI3L2
SCHEMBL22903626 0.91 KCNH2 (0.70) CHIT1CHIAKCNH2CHI3L1CHI3L2
SCHEMBL18607770 0.90 KCNH2 (0.71) CHIT1CHIAKCNH2CHI3L1CHI3L2
SCHEMBL18577410 0.90 KCNH2 (0.71) CHIT1CHIAKCNH2CHI3L1CHI3L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3344616-B1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS ONCOARENDI THERAPEUTICS SA (PL) 2019-01-09 — — EP disclosed
US-9944624-B2 Substituted amino triazoles useful as human chitinase inhibitors Oncoarendi Therapeutics S.A. (PL) 2018-04-17 — — US disclosed
US-20170066743-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS GALAPAGOS NV (BE) 2017-03-09 — — US disclosed
WO-2017037670-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS OncoArendi Therapeutics Sp. z o.o. (PL) 2017-03-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170066743-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS CHIA, CHIT1, AADAC CHIT1 2/4885CHIA 1/4885KCNH2 3882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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