Sugi Predict

Sugi Predict / Targets / CHIT1

CHIT1

Chitotriosidase-1 · Q13231 · CHIT1 on Sugi Atlas →

5,981 patent compounds predicted against CHIT1, 3,499 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1968987 SCHEMBL1968987 0.54 7/20
SCHEMBL5212497 SCHEMBL5212497 0.44 7/20
SCHEMBL1242233 SCHEMBL1242233 0.55 6/20
SCHEMBL1967611 SCHEMBL1967611 0.54 6/20
SCHEMBL2455907 SCHEMBL2455907 0.46 6/20
SCHEMBL652789 SCHEMBL652789 0.34 5/20
SCHEMBL652790 SCHEMBL652790 0.34 5/20
SCHEMBL1994355 SCHEMBL1994355 0.45 4/20
SCHEMBL7621086 SCHEMBL7621086 0.45 4/20
SCHEMBL5779838 SCHEMBL5779838 0.50 3/20
SCHEMBL1969047 SCHEMBL1969047 0.46 3/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL7523050) 0.44 3/20
SCHEMBL3154343 SCHEMBL3154343 0.48 2/20
SCHEMBL6836212 SCHEMBL6836212 0.46 2/20
SCHEMBL6836213 SCHEMBL6836213 0.46 2/20
SCHEMBL8481125 SCHEMBL8481125 0.44 2/20
SCHEMBL8481128 SCHEMBL8481128 0.44 2/20
SCHEMBL8186149 SCHEMBL8186149 0.44 2/20
SCHEMBL4649492 SCHEMBL4649492 0.43 2/20
SCHEMBL586739 SCHEMBL586739 0.43 2/20

Clinical trials — most relevant to CHIT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase 3b Study to Evaluate Skeletal Response to Eliglustat in Adult Patients Who Completed Phase 2 or Phase 3 Studies PHASE3COMPLETED
A Study of GlcNAc on Tear Production in NGLY1-CDDG PHASE2ACTIVE_NOT_RECRUITING
Phase 1/2 Study of CAN103 in Subjects With Gaucher Disease PHASE1/PHASE2UNKNOWN
A Single Ascending Dose Study of CD101 IV in Healthy Subjects PHASE1COMPLETED
CD5CAR-NK Cells for Refractory Invasive Mold Disease PHASE1NOT_YET_RECRUITING
The Natural History of Alpha-Mannosidosis nanCOMPLETED
Exploration of Immunity in Gaucher Disease nanCOMPLETED
Chitinases and Transforming Growth Factor Beta (TGFB) in Human Asthma nanCOMPLETED
Biomarker for Mannosidosis Disease (BioMannosidosis) nanWITHDRAWN
Duplication in CHIT1 Gene and the Risk for Aspergillus Lung Disease in CF Patients nanCOMPLETED
Biomarkers Related to Bone in Pediatric Gaucher Disease nanUNKNOWN
The Role of Peripheral and Tissue Chitinase 3-like 1 Protein Levels as a Bio-marker in IBD nanCOMPLETED
Cardiovascular Structure and Function in the Mucopolysaccharidoses nanACTIVE_NOT_RECRUITING
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED
Biomarker for Gaucher Disease: BioGaucher (BioGaucher) nanWITHDRAWN
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML) nanWITHDRAWN
Lyso-Gb1 as a Long-term Prognostic Biomarker in Gaucher Disease nanCOMPLETED
Biomarker for Farber Disease (BioFarber) nanWITHDRAWN
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection nanCOMPLETED
Validating a New Severity Score System for Adults With Type 1 Gaucher Disease (GD1) nanCOMPLETED
Registry Gangliosidoses nanUNKNOWN
Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients nanUNKNOWN
The Connection Between Liver Disease and Chitinase Proteins nanUNKNOWN
Histoblood Group Antigens as a Risk Factor of Asthma nanCOMPLETED
Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing nanUNKNOWN
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease nanUNKNOWN
Efficacy of an Intravaginal Treatment With Carboxymethyl-β-glucan and Polycarbophil in HR-HPV Clearance nanUNKNOWN
Unrelated Donor BMT for Treatment of Patients With PGK Deficiency nanCOMPLETED
A Retrospective Study to Identify New Omics Biomarkers of Chronic/Persistent Low Back Pain nanCOMPLETED
Comparison of Uncomplicated Candidemia Therapy Duration in Children nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a CHIT1 binder may also engage these)

ProteinNameSimilarity
Q9D7Q1 — 0.991 Q9D7Q1 →
Q9WTV1 — 0.986 Q9WTV1 →
Q6RY07 — 0.986 Q6RY07 →
Q61362 — 0.986 Q61362 →
Q5RBP6 — 0.985 Q5RBP6 →
CHI3L1 Chitinase-3-like protein 1 0.984 landscape →
Q95M17 — 0.984 Q95M17 →
Q29411 — 0.983 Q29411 →
P30922 — 0.981 P30922 →
Q7YS85 — 0.980 Q7YS85 →
O35744 — 0.980 O35744 →
CHI3L2 Chitinase-3-like protein 2 0.979 landscape →
Q91XA9 — 0.979 Q91XA9 →
CHIA Acidic mammalian chitinase 0.978 landscape →
Q91Z98 — 0.977 Q91Z98 →
Q8SPQ0 — 0.976 Q8SPQ0 →
Q6TMG6 — 0.972 Q6TMG6 →
Q11174 — 0.972 Q11174 →
Q2PQM7 — 0.969 Q2PQM7 →
C5P230 — 0.967 C5P230 →
HEXA Beta-hexosaminidase subunit alpha 0.967 landscape →
P0CB51 — 0.967 P0CB51 →
Q1E3R8 — 0.966 Q1E3R8 →
Q2KIM0 — 0.966 Q2KIM0 →
E9QRF2 — 0.966 E9QRF2 →
Q8T0R7 — 0.965 Q8T0R7 →
P29030 — 0.965 P29030 →
P32470 — 0.965 P32470 →
P31428 — 0.965 P31428 →
P17164 — 0.964 P17164 →