Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13155583 | 0.86 | ACACB (0.53) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL123415 | 0.81 | MAPT (0.55) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL8048422 | 0.80 | MAPT (0.53) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL24451691 | 0.80 | ACACB (0.46) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL15114294 | 0.79 | LMNA (0.57) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL31545989 | 0.78 | SLC6A4 (0.59) | LMNASLC6A4 | |
| SCHEMBL7477540 | 0.78 | NPC1 (0.54) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL4527180 | 0.78 | MAPT (0.50) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL17484657 | 0.78 | ACACB (0.53) | ACACBMAPTMEN1ALOX12KMT2A | |
| SCHEMBL8047274 | 0.77 | ACACB (0.52) | ACACBMAPTMEN1ALOX12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344603-B1 | A PRODUCTION METHOD OF 1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1-METHYLPIPERIDIN- 4 YL)UREA AND ITS DEUTERATED ANALOGS NOT CONTAINING DIMERIC IMPURITIES | ZENTIVA KS (CZ) | 2020-09-30 | — | — | EP | disclosed |
| WO-2017036432-A1 | A PRODUCTION METHOD OF 1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1-METHYLPIPERIDIN- 4— YL)UREA AND ITS DEUTERATED ANALOGS NOT CONTAINING DIMERIC IMPURITIES | ZENTIVA, K.S. (CZ) | 2017-03-09 | — | — | WO | disclosed |