Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHIT1 | Q13231 | 14/20 | 0.57 |
| ▸ | CHIA | Q9BZP6 | 13/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.57 |
| ▸ | CHI3L1 | P36222 | 8/20 | 0.57 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18607914 | 1.00 | CHIT1 (0.57) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL18577482 | 1.00 | CHIT1 (0.57) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL18589408 | 1.00 | CHIT1 (0.57) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL18589399 | 0.91 | CHIT1 (0.60) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL18577086 | 0.91 | CHIT1 (0.60) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL26439036 | 0.91 | KCNH2 (0.57) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL18610245 | 0.91 | CHIT1 (0.60) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL18609556 | 0.91 | CHIT1 (0.60) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL22903590 | 0.91 | KCNH2 (0.57) | CHIT1CHIAKCNH2CHI3L1CHI3L2 | |
| SCHEMBL23169723 | 0.90 | CHIA (0.58) | CHIT1CHIAKCNH2CHI3L1CHI3L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344616-B1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS | ONCOARENDI THERAPEUTICS SA (PL) | 2019-01-09 | — | — | EP | disclosed |
| WO-2017037670-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2017-03-09 | — | — | WO | disclosed |