Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.48 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23305963 | 0.85 | GPR119 (0.49) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL29840299 | 0.85 | GPR119 (0.49) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL19914349 | 0.84 | MAP4K4 (0.51) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL23983662 | 0.84 | GPR119 (0.48) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL20163031 | 0.84 | CKS1B (0.50) | GPR119CKS1BSKP1SKP2MAPT | |
| Lithium Ion SCHEMBL20163049 | 0.82 | GPR119 (0.47) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL20163046 | 0.82 | GPR119 (0.47) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL29215354 | 0.81 | MAPT (0.47) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL26074182 | 0.81 | CKS1B (0.52) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL22738193 | 0.79 | GPR119 (0.44) | GPR119CKS1BSKP1SKP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3347018-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Dana-Farber Cancer Institute, Inc. (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2017044858-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-03-16 | — | — | WO | disclosed |