Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 10/20 | 0.43 |
| ▸ | AXL | P30530 | 10/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18611170 | 0.84 | MERTK (0.48) | MERTKAXLHDAC1PIK3C3BMPR1B | |
| SCHEMBL18580406 | 0.73 | AXL (0.83) | MERTKAXL | |
| SCHEMBL18617173 | 0.72 | HRH3 (0.50) | LRRK2 | |
| SCHEMBL18615349 | 0.71 | MERTK (0.61) | MERTKAXLPIK3C3BMPR1BBMPR1A | |
| SCHEMBL4089510 | 0.70 | MET (0.55) | MERTKAXLBMPR1AACVRL1ACVR1 | |
| SCHEMBL23686815 | 0.69 | CXCR4 (0.50) | — | |
| SCHEMBL18617171 | 0.67 | AXL (0.49) | MERTKAXLLRRK2BMPR1BBMPR1A | |
| SCHEMBL18615838 | 0.67 | MAP4K4 (0.51) | MAP4K4 | |
| SCHEMBL16293110 | 0.66 | KDM2B (0.38) | — | |
| SCHEMBL18611756 | 0.66 | MERTK (0.61) | MERTKAXLPIK3C3BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |