Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | CDK8 | P49336 | 3/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sc-43 SCHEMBL29492117 | 0.94 | RAF1 (0.67) | RAF1KDRCDK8EPHX2CA1 | |
| Sc-43 SCHEMBL29367145 | 0.94 | RAF1 (0.67) | RAF1KDRCDK8EPHX2CA1 | |
| Sc-43 SCHEMBL14684295 | 0.94 | RAF1 (0.67) | RAF1KDRCDK8EPHX2CA1 | |
| SCHEMBL15746582 | 0.86 | KDR (0.74) | RAF1KDRCDK8EPHX2CA1 | |
| SCHEMBL16620784 | 0.85 | KDR (0.73) | RAF1KDRCDK8EPHX2CA7 | |
| SCHEMBL16480213 | 0.85 | RAF1 (0.56) | RAF1KDRCDK8EPHX2CA1 | |
| SCHEMBL6030307 | 0.84 | RET (0.63) | RAF1KDRCDK8EPHX2CA1 | |
| SCHEMBL18615962 | 0.83 | KDR (0.67) | RAF1KDRCDK8EPHX2CA1 | |
| SCHEMBL18615686 | 0.82 | CDK8 (0.65) | RAF1KDRCDK8CA1CA2 | |
| SCHEMBL16628097 | 0.81 | KDR (0.59) | RAF1KDRCDK8EPHX2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-08-18 | — | — | US | disclosed |
| WO-2017036405-A1 | COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY | 陈昆锋 | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | PTPRCAP, PTPN18, PTPN1 | RAF1 404/4885KDR 621/4885CDK8 2469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.