Sc-43

Sc-43

SCHEMBL29367145

N#Cc1ccc(Oc2cccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)cc1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 9/20 0.67
KDR P35968 3/20 0.67
CDK8 P49336 3/20 0.66
CA1 P00915 1/20 0.61
CA2 P00918 1/20 0.61
CA7 P43166 1/20 0.61
CA9 Q16790 1/20 0.61
EPHX2 P34913 1/20 0.60
RET P07949 1/20 0.60
BRAF P15056 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sc-43 SCHEMBL14684295 1.00 RAF1 (0.67) RAF1KDRCDK8CA1CA2
Sc-43 SCHEMBL29492117 1.00 RAF1 (0.67) RAF1KDRCDK8CA1CA2
SCHEMBL18615606 0.94 RAF1 (0.59) RAF1KDRCDK8CA1CA2
SCHEMBL15746582 0.92 KDR (0.74) RAF1KDRCDK8CA1CA2
SCHEMBL16480213 0.92 RAF1 (0.56) RAF1KDRCDK8CA1CA2
SCHEMBL16620784 0.92 KDR (0.73) RAF1KDRCDK8CA7CA9
SCHEMBL18615962 0.90 KDR (0.67) RAF1KDRCDK8CA1CA2
SCHEMBL18615686 0.89 CDK8 (0.65) RAF1KDRCDK8CA1CA2
SCHEMBL18616000 0.87 KDR (0.64) RAF1KDRCDK8CA1CA2
SCHEMBL18615368 0.87 BRAF (0.59) RAF1KDRCDK8CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12514938-B2 Fibroblast activation protein targeting peptides PERSPECTIVE THERAPEUTICS, INC. (US) 2026-01-06 US claimed
US-20250332296-A1 ZWITTERIONIC METAL CHELATORS CURADEL SURGICAL INNOVATIONS, INC. (US) 2025-10-30 US claimed
EP-4619043-B1 FIBROBLAST ACTIVATION PROTEIN TARGETED COMPOUNDS AND USE THEREOF PERSPECTIVE THERAPEUTICS INC (US) 2025-10-29 EP claimed
EP-4619043-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED COMPOUNDS AND USE THEREOF Perspective Therapeutics, Inc. (US) 2025-09-24 EP claimed
EP-4611825-A1 RADIOPHARMACEUTICAL MOFS FOR MEDICAL IMAGING Node Pharma AS (NO) 2025-09-10 EP claimed
US-20250262335-A1 PSMA-Targeting Ligands with Optimal Properties for Imaging and Therapy WISCONSIN ALUMNI RESEARCH FOUNDATION 2025-08-21 US claimed
WO-2025128149-A1 FIBROBLAST ACTIVATION PROTEIN TARGETED COMPOUNDS AND USE THEREOF VIEWPOINT MOLECULAR TARGETING, INC. (US) 2025-06-19 WO claimed
US-20250186630-A1 FIBROBLAST ACTIVATION PROTEIN TARGETING PEPTIDES VIEWPOINT MOLECULAR TARGETING, INC. (US) 2025-06-12 US claimed
WO-2025119203-A1 HETERODIMER RADIONUCLIDE DRUG CONJUGATE, AND PREPARATION THEREFOR AND USE THEREOF 烟台蓝纳成生物技术有限公司 2025-06-12 WO claimed
US-20250186632-A1 FIBROBLAST ACTIVATION PROTEIN TARGETING PEPTIDES VIEWPOINT MOLECULAR TARGETING, INC. 2025-06-12 US claimed
EP-4326246-A1 PSMA-TARGETING LIGANDS WITH OPTIMAL PROPERTIES FOR IMAGING AND THERAPY Wisconsin Alumni Research Foundation (US) 2024-02-28 EP claimed
CN-117180254-A Application of SC-43 in preparation of medicine for resisting gram-positive bacterial infection 华中科技大学协和深圳医院 2023-12-08 CN claimed
US-20230302164-A1 PSMA-Targeting Ligands With Optimal Properties for Imaging and Therapy WISCONSIN ALUMNI RESEARCH FOUNDATION 2023-09-28 US claimed
WO-2023150540-A1 HYDROXAMIC ACID MACROCYCLIC AGENTS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF LUMIPHORE, INC. (US) 2023-08-10 WO claimed
WO-2023104744-A1 3-((3-([1,1'-BIPHENYL]-3-YLMETHOXY)PHENOXY)METHYL)BENZONITRILE DERIVATIVES AND THE USE THEREOF HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF E.V. (DE) 2023-06-15 WO claimed
US-20230173112-A1 PSMA-Targeting Ligands With Optimal Properties for Imaging and Therapy WISCONSIN ALUMNI RESEARCH FOUNDATION 2023-06-08 US claimed
US-20230025025-A1 SUBSTITUTED PYRAZOLE AMIDES GRUENENTHAL GMBH (DE) 2023-01-26 US claimed
WO-2022263498-A1 SUBSTITUTED PYRAZOLE AMIDES Grünenthal GmbH (DE) 2022-12-22 WO claimed
WO-2022226326-A1 PSMA-TARGETING LIGANDS WITH OPTIMAL PROPERTIES FOR IMAGING AND THERAPY WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2022-10-27 WO claimed
CN-109789116-B Use of SC-43 for improving fibrosis 陈昆锋 2022-02-01 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230173112-A1 PSMA-Targeting Ligands With Optimal Properties for Imaging and Therapy PSMA1, PSMA2, FOLH1 RAF1 4851/4885KDR 3905/4885CDK8 2924/4885
US-20250262335-A1 PSMA-Targeting Ligands with Optimal Properties for Imaging and Therapy PSMA1, PSMA2, FOLH1 RAF1 4844/4885KDR 4008/4885CDK8 2835/4885
US-20250186630-A1 FIBROBLAST ACTIVATION PROTEIN TARGETING PEPTIDES FAP, FIBP, TPX2 RAF1 1997/4885KDR 2487/4885CDK8 3533/4885
US-20230302164-A1 PSMA-Targeting Ligands With Optimal Properties for Imaging and Therapy PSMA1, PSMA2, FOLH1 RAF1 4844/4885KDR 4008/4885CDK8 2835/4885
US-20250186632-A1 FIBROBLAST ACTIVATION PROTEIN TARGETING PEPTIDES FAP, FIBP, LAP3 RAF1 1928/4885KDR 2498/4885CDK8 2786/4885
US-20230025025-A1 SUBSTITUTED PYRAZOLE AMIDES SCN8A, SCN1A, SCN7A RAF1 934/4885KDR 2752/4885CDK8 373/4885
US-20250332296-A1 ZWITTERIONIC METAL CHELATORS SLC39A14, SLC7A1, SLC39A11 RAF1 4712/4885KDR 1739/4885CDK8 2082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.