Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 6/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | MET | P08581 | 3/20 | 0.45 |
| ▸ | TEK | Q02763 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615997 | 0.93 | KDR (0.50) | KDREPHX2RAF1PLA2G7BRAF | |
| SCHEMBL18615565 | 0.91 | KDR (0.47) | KDRBRAFLCKMETTEK | |
| SCHEMBL18615384 | 0.85 | KDR (0.47) | KDRBRAFLCKMETTEK | |
| SCHEMBL18615372 | 0.84 | KDR (0.46) | KDRBRAFMAPK14LCKMET | |
| SCHEMBL18615929 | 0.84 | MAPT (0.48) | KDREPHX2BRAFMAPTTP53 | |
| SCHEMBL18615354 | 0.80 | KDR (0.51) | KDRLCKMETTEKMAPT | |
| SCHEMBL18615587 | 0.79 | KDR (0.47) | KDRLCKMETTEKMAPT | |
| SCHEMBL18615705 | 0.78 | MAPT (0.46) | KDREPHX2BRAFMAPTTP53 | |
| SCHEMBL18615555 | 0.78 | PTGDR2 (0.46) | KDRBRAFMAPK14MAPTTP53 | |
| SCHEMBL15746582 | 0.77 | KDR (0.74) | KDREPHX2RAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026035-B | Compounds having protein tyrosine phosphatase SHP-1 agonist activity | 陈昆锋 | 2021-03-30 | — | — | CN | disclosed |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-08-18 | — | — | US | disclosed |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-08-18 | — | — | US | disclosed |
| US-20180237385-A1 | AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 | NATIONAL TAIWAN UNIVERSITY (TW) | 2018-08-23 | — | — | US | disclosed |
| EP-3345894-A1 | COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY | Chen, Kuenfeng (TW) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017036405-A1 | COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY | 陈昆锋 | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180237385-A1 | AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 | PTPRCAP, PTPN18, PTPN1 | KDR 621/4885EPHX2 3833/4885RAF1 404/4885 |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | PTPRCAP, PTPN18, PTPN1 | KDR 621/4885EPHX2 3833/4885RAF1 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.