Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IL18 | Q14116 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615384 | 0.93 | KDR (0.47) | MAPTTHRBTP53LMNARXFP1 | |
| SCHEMBL18615555 | 0.92 | PTGDR2 (0.46) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL18615929 | 0.86 | MAPT (0.48) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL20357558 | 0.86 | MAPT (0.52) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL18615997 | 0.85 | KDR (0.50) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL18615372 | 0.85 | KDR (0.46) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL18615347 | 0.81 | MAPT (0.51) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL18615928 | 0.81 | MAPT (0.46) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL18615565 | 0.79 | KDR (0.47) | MAPTTHRBTP53POLBLMNA | |
| SCHEMBL18615701 | 0.78 | KDR (0.50) | MAPTTHRBTP53POLBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026035-B | Compounds having protein tyrosine phosphatase SHP-1 agonist activity | 陈昆锋 | 2021-03-30 | — | — | CN | disclosed |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-08-18 | — | — | US | disclosed |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-08-18 | — | — | US | disclosed |
| US-20180237385-A1 | AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 | NATIONAL TAIWAN UNIVERSITY (TW) | 2018-08-23 | — | — | US | disclosed |
| WO-2017036405-A1 | COMPOUND HAVING PROTEIN TYROSINE PHOSPHATASE SHP-1 AGONIST ACTIVITY | 陈昆锋 | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180237385-A1 | AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1 | PTPRCAP, PTPN18, PTPN1 | MAPT 4678/4885THRB 400/4885TP53 424/4885 |
| US-10745346-B2 | Agonists of protein tyrosine phosphatase SHP-1 | PTPRCAP, PTPN18, PTPN1 | MAPT 4678/4885THRB 400/4885TP53 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.