Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 11/20 | 0.62 |
| ▸ | MERTK | Q12866 | 10/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.59 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.55 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.55 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.55 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615786 | 0.88 | AXL (0.57) | AXLMERTKFLT3TYRO3TNIK | |
| SCHEMBL18616643 | 0.82 | AXL (0.66) | AXLMERTKFLT3TYRO3BMPR1B | |
| SCHEMBL18616607 | 0.81 | MERTK (0.65) | AXLMERTKBMPR1BBMPR1AACVRL1 | |
| SCHEMBL18579849 | 0.80 | AXL (0.94) | AXLMERTKFLT3TYRO3 | |
| SCHEMBL18617088 | 0.79 | AXL (0.68) | AXLMERTKFLT3TYRO3 | |
| SCHEMBL18580177 | 0.78 | AXL (0.90) | AXLMERTKFLT3TYRO3 | |
| SCHEMBL18615800 | 0.78 | AXL (0.56) | AXLMERTKFLT3TYRO3BMPR1B | |
| SCHEMBL18580382 | 0.77 | AXL (0.88) | AXLMERTKFLT3TYRO3 | |
| SCHEMBL18580176 | 0.77 | MERTK (1.00) | AXLMERTKFLT3TYRO3 | |
| SCHEMBL18579696 | 0.77 | AXL (0.97) | AXLMERTKFLT3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |