Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 16/20 | 0.66 |
| ▸ | MERTK | Q12866 | 15/20 | 0.66 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.59 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.59 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.59 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.59 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21779434 | 0.88 | AXL (0.60) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616607 | 0.84 | MERTK (0.65) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL24838113 | 0.82 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616319 | 0.82 | MERTK (0.58) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18615845 | 0.82 | AXL (0.62) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18580228 | 0.80 | AXL (1.00) | AXLMERTK | |
| SCHEMBL19806892 | 0.79 | ACVR1 (0.77) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL18616320 | 0.78 | AXL (0.60) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL28701689 | 0.78 | AXL (0.50) | AXLMERTKBMPR1BBMPR1ATGFBR1 | |
| SCHEMBL18616322 | 0.77 | AXL (0.55) | AXLMERTKBMPR1BBMPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |