Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18585872 | 0.89 | MPO (0.52) | MPOLMNAKLKB1ALDH1A1 | |
| SCHEMBL18586304 | 0.87 | MPO (0.49) | MPOLMNAKLKB1ALDH1A1 | |
| SCHEMBL18586149 | 0.86 | MPO (0.66) | MPOKLKB1L3MBTL1 | |
| SCHEMBL18617374 | 0.85 | MPO (0.45) | MPOKLKB1ALDH1A1 | |
| SCHEMBL18617179 | 0.85 | MPO (0.45) | MPOKLKB1ALDH1A1 | |
| SCHEMBL18585880 | 0.85 | MPO (0.44) | MPOKLKB1 | |
| SCHEMBL18617587 | 0.85 | MPO (0.58) | MPOKLKB1L3MBTL1 | |
| SCHEMBL18585603 | 0.84 | MPO (0.45) | MPOKLKB1 | |
| SCHEMBL18586276 | 0.83 | KLKB1 (0.45) | MPOKLKB1 | |
| SCHEMBL18618057 | 0.83 | KLKB1 (0.51) | MPOLMNAKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |