Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 9/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TPO | P07202 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617530 | 0.85 | MPO (0.52) | MPOKLKB1HDAC1ADORA2AADORA1 | |
| SCHEMBL18617589 | 0.85 | MPO (0.53) | MPOKLKB1HDAC1ADORA2AADORA1 | |
| SCHEMBL18616605 | 0.85 | MPO (0.60) | MPOKLKB1ADORA2AADORA1L3MBTL1 | |
| SCHEMBL18618077 | 0.83 | MPO (0.43) | MPOKLKB1ADORA2AADORA1L3MBTL1 | |
| SCHEMBL18617761 | 0.82 | MPO (0.52) | MPOKLKB1L3MBTL1TPOCYP3A4 | |
| SCHEMBL18616429 | 0.82 | MPO (0.48) | MPOKLKB1HDAC1ADORA2AADORA1 | |
| SCHEMBL18617253 | 0.81 | MPO (0.52) | MPOKLKB1ADORA2AADORA1 | |
| SCHEMBL18616533 | 0.80 | MPO (0.49) | MPOKLKB1TPOCYP3A4 | |
| SCHEMBL18616600 | 0.79 | MPO (0.48) | MPOKLKB1HDAC1TPOCYP3A4 | |
| SCHEMBL18616433 | 0.78 | MPO (0.44) | MPOKLKB1HDAC1BACE1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |