Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434664 | 0.84 | HCAR2 (0.47) | HCAR2HDAC4SLC6A3KDM4EPKM | |
| SCHEMBL28112074 | 0.79 | HCAR2 (0.43) | HCAR2SMN1; SMN2 | |
| SCHEMBL27736514 | 0.79 | KMT2A (0.48) | HCAR2SLC6A3KDM4EPKMSMN1; SMN2 | |
| SCHEMBL15201005 | 0.78 | HCAR2 (0.31) | HCAR2KDM4E | |
| SCHEMBL10360739 | 0.76 | HCAR2 (0.31) | HCAR2 | |
| SCHEMBL4030060 | 0.76 | CSNK2A1 (0.42) | HCAR2SLC6A3KDM4ESMN1; SMN2HDAC1 | |
| SCHEMBL3719139 | 0.76 | SMN1; SMN2 (0.37) | SLC6A3KDM4ESMN1; SMN2 | |
| SCHEMBL23829538 | 0.74 | HCAR2 (0.39) | HCAR2KDM4ESMN1; SMN2 | |
| SCHEMBL186142 | 0.73 | CCNE1 (0.47) | — | |
| SCHEMBL7505061 | 0.73 | RECQL (0.35) | KDM4EPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108744-A1 | NOVEL SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE OF SAME TO PRODUCE DRUGS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-06-29 | — | — | WO | disclosed |
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| EP-0037471-A1 | 1-Aroyl-2-phenylamino-2-imidazolines, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | disclosed |