Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 15/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | BRD1 | O95696 | 1/20 | 0.37 |
| ▸ | CCL2 | P13500 | 1/20 | 0.37 |
| ▸ | TAF1 | P21675 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20494532 | 0.88 | ESR2 (0.41) | ESR2BRD4NR1H2NPC1RAB9A | |
| SCHEMBL18616953 | 0.83 | BRD4 (0.61) | BRD4TRIM24BRD1CCL2TAF1 | |
| SCHEMBL5663106 | 0.76 | ESR2 (0.43) | ESR2NR1H2NPC1RAB9AVEGFA | |
| SCHEMBL18584548 | 0.74 | BRD4 (0.47) | BRD4TRIM24BRD1CCL2TAF1 | |
| SCHEMBL5661745 | 0.74 | ESR2 (0.43) | ESR2NR1H2NPC1RAB9AJAK2 | |
| SCHEMBL31281068 | 0.73 | ESR2 (0.59) | ESR2NR1H2NPC1RAB9AJAK2 | |
| SCHEMBL12608362 | 0.73 | ESR2 (0.59) | ESR2NR1H2NPC1RAB9AJAK2 | |
| SCHEMBL18617017 | 0.73 | BRD4 (0.58) | BRD4TRIM24BRD1CCL2TAF1 | |
| SCHEMBL18689499 | 0.73 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2TAF1 | |
| SCHEMBL18616184 | 0.72 | BRD4 (0.48) | BRD4TRIM24BRD1CCL2TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017037116-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-09 | — | — | WO | disclosed |