Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 7/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18616571 | 0.90 | MPO (0.47) | MPOKLKB1KDM4EALDH1A1LMNA | |
| SCHEMBL18616605 | 0.90 | MPO (0.60) | MPOKLKB1 | |
| SCHEMBL18616392 | 0.89 | CYP3A4 (0.45) | MPOKLKB1KDM4EALDH1A1LMNA | |
| SCHEMBL18617589 | 0.88 | MPO (0.53) | MPOKLKB1 | |
| SCHEMBL18617603 | 0.87 | MPO (0.45) | MPOKLKB1KDM4EALDH1A1LMNA | |
| SCHEMBL18617565 | 0.86 | HSD17B10 (0.48) | MPOKLKB1KDM4EALDH1A1LMNA | |
| SCHEMBL18616380 | 0.84 | MPO (0.43) | MPOKLKB1 | |
| SCHEMBL18618067 | 0.84 | MPO (0.43) | MPOKLKB1KCNH2LMNAMAPT | |
| SCHEMBL18617197 | 0.84 | MPO (0.42) | MPOKLKB1 | |
| SCHEMBL18616542 | 0.84 | MPO (0.48) | MPOKLKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |