Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 20/20 | 0.81 |
| ▸ | NSD2 | O96028 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | BID | P55957 | 1/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.69 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.69 |
| ▸ | ASPH | Q12797 | 1/20 | 0.69 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.69 |
| ▸ | BAD | Q92934 | 1/20 | 0.69 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.69 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27075547 | 0.94 | BCL2 (0.83) | BCL2 | |
| SCHEMBL1870981 | 0.92 | BCL2 (0.74) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL1699863 | 0.91 | BCL2 (0.96) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL1699862 | 0.91 | BCL2 (0.96) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL29657408 | 0.91 | BCL2 (0.96) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL19292332 | 0.91 | BCL2 (0.83) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL1863433 | 0.90 | BCL2 (0.83) | BCL2 | |
| SCHEMBL21573216 | 0.90 | BCL2 (0.73) | BCL2NSD2ADORA3CYP2C9ADRA2C | |
| SCHEMBL8515424 | 0.90 | BCL2 (0.76) | BCL2 | |
| SCHEMBL1701506 | 0.89 | BCL2 (1.00) | BCL2NSD2ADORA3CYP2C9ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | claimed |
| WO-2010138588-A9 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | claimed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | claimed |