Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22798190 | 1.00 | ACE (0.53) | ACELMNASMN1; SMN2PREPLTA4H | |
| SCHEMBL20484685 | 0.91 | FKBP1A (0.53) | ACELMNAPREPSIGMAR1 | |
| SCHEMBL18620609 | 0.91 | FKBP1A (0.53) | ACELMNAPREPSIGMAR1 | |
| SCHEMBL10660541 | 0.89 | ACE (0.54) | ACELMNASMN1; SMN2PREPLTA4H | |
| SCHEMBL7264861 | 0.85 | ACE (0.53) | ACELMNALTA4HACE2 | |
| Cyclohexylamine SCHEMBL10724532 | 0.85 | ACE (0.49) | ACELMNASMN1; SMN2SIGMAR1ACE2 | |
| SCHEMBL24579410 | 0.83 | ACE (0.44) | ACELMNASMN1; SMN2LTA4HACE2 | |
| SCHEMBL29696654 | 0.83 | ACE (0.44) | ACELMNASMN1; SMN2LTA4HACE2 | |
| SCHEMBL29697693 | 0.83 | ACE (0.44) | ACELMNASMN1; SMN2LTA4HACE2 | |
| SCHEMBL26605894 | 0.83 | ACE (0.44) | ACELMNASMN1; SMN2LTA4HACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341007-B1 | MALT1 INHIBITORS AND USES THEREOF | UNIV CORNELL (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3341007-B1 | MALT1 INHIBITORS AND USES THEREOF | UNIV CORNELL (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2017040304-A1 | MALT1 INHIBITORS AND USES THEREOF | CORNELL UNIVERSITY (US) | 2017-03-09 | — | — | WO | disclosed |