Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | FAAH | O00519 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MGLL | Q99685 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3026559 | 0.92 | CYP2C9 (0.67) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL14263092 | 0.91 | TACR3 (0.59) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL2931988 | 0.87 | TACR3 (0.75) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL14559866 | 0.85 | MEN1 (0.53) | TACR3MEN1KMT2AALDH1A1POLB | |
| SCHEMBL21763292 | 0.84 | TACR3 (0.71) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL1761001 | 0.84 | TACR3 (0.71) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL13589533 | 0.84 | L3MBTL1 (0.68) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL12000466 | 0.84 | TACR3 (0.66) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL14930107 | 0.84 | TACR3 (0.66) | TACR3CYP2C9CYP2C19MAPK14HTR2B | |
| SCHEMBL21081443 | 0.84 | TACR3 (0.66) | TACR3CYP2C9CYP2C19MAPK14HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040450-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |