Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 10/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185811 | 0.91 | BDKRB1 (0.37) | FAAHTRPV1BDKRB1CNR1 | |
| SCHEMBL2808015 | 0.89 | BDKRB1 (0.47) | BDKRB1CNR1 | |
| SCHEMBL14856578 | 0.89 | BDKRB1 (0.34) | FAAHTRPV1BDKRB1CNR1CACNA1G | |
| SCHEMBL14856870 | 0.88 | BDKRB1 (0.38) | FAAHTRPV1BDKRB1CNR1 | |
| SCHEMBL186046 | 0.83 | BDKRB1 (0.36) | FAAHTRPV1BDKRB1 | |
| SCHEMBL186430 | 0.82 | BDKRB1 (0.33) | FAAHTRPV1BDKRB1 | |
| SCHEMBL186533 | 0.82 | BDKRB1 (0.33) | FAAHTRPV1BDKRB1 | |
| SCHEMBL14856869 | 0.82 | BDKRB1 (0.37) | TRPV1BDKRB1CNR2 | |
| SCHEMBL185223 | 0.81 | FAAH (0.35) | FAAHTRPV1 | |
| SCHEMBL3722571 | 0.80 | CACNA1I (0.36) | BDKRB1CNR1CACNA1GCACNA1HCACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |