Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.46 |
| ▸ | MEN1 | O00255 | 10/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20672109 | 0.81 | MAPT (0.44) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL17595330 | 0.80 | MAPT (0.54) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL17595329 | 0.80 | MAPT (0.54) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL17595117 | 0.78 | MAPT (0.51) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL17595119 | 0.78 | MAPT (0.51) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL19295489 | 0.78 | MAPT (0.48) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL18586819 | 0.77 | MPO (0.50) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL18586823 | 0.77 | MPO (0.50) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL18616415 | 0.76 | MAPT (0.41) | MAPTRECQLKMT2AMEN1MAPK1 | |
| SCHEMBL18586035 | 0.76 | MAPT (0.45) | MAPTRECQLKMT2ATDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040451-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |