Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.59 |
| ▸ | POLA1 | P09884 | 1/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | OSBP | P22059 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 2/20 | 0.54 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | NPC1L1 | Q9UHC9 | 5/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | FGF2 | P09038 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CRYAB | P02511 | 1/20 | 0.48 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 2/20 | 0.48 |
| ▸ | UGCG | Q16739 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17212337 | 1.00 | CYP46A1 (0.59) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL10237705 | 0.91 | CYP46A1 (0.63) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL25747241 | 0.91 | CYP46A1 (0.63) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL25797981 | 0.90 | CYP46A1 (0.62) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL17212335 | 0.90 | POLA1 (0.51) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL18622141 | 0.90 | POLA1 (0.51) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL16476474 | 0.88 | CYP46A1 (0.67) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL19566728 | 0.88 | CYP46A1 (0.67) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL24473940 | 0.88 | CYP46A1 (0.68) | CYP46A1POLA1NR1H3USP2OSBP | |
| SCHEMBL19578615 | 0.88 | CYP46A1 (0.68) | CYP46A1POLA1NR1H3USP2OSBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593155-B2 | Oxyntomodulin analogs | MERCK SHARP & DOHME CORP. (US) | 2017-03-14 | — | — | US | disclosed |