Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.68 |
| ▸ | POLA1 | P09884 | 1/20 | 0.65 |
| ▸ | OSBP | P22059 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | RORC | P51449 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.57 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.54 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GBA1 | P04062 | 2/20 | 0.52 |
| ▸ | UGCG | Q16739 | 2/20 | 0.52 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | FGF2 | P09038 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19578615 | 1.00 | CYP46A1 (0.68) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL16476474 | 0.93 | CYP46A1 (0.67) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL19566728 | 0.93 | CYP46A1 (0.67) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL16104245 | 0.91 | CYP46A1 (0.64) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL25747241 | 0.91 | CYP46A1 (0.63) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL10237705 | 0.91 | CYP46A1 (0.63) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL14964148 | 0.90 | CYP46A1 (0.70) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL24917535 | 0.90 | POLA1 (0.69) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL25797981 | 0.90 | CYP46A1 (0.62) | CYP46A1POLA1OSBPUSP2RORC | |
| SCHEMBL16087280 | 0.89 | CYP46A1 (0.57) | CYP46A1POLA1OSBPUSP2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11872261-B2 | Lipoprotein targeting protease inhibitors and uses | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2024-01-16 | — | — | US | disclosed |
| US-20220168379-A1 | LIPOPROTEIN TARGETING PROTEASE INHIBITORS AND USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11872261-B2 | Lipoprotein targeting protease inhibitors and uses | SERPINB1, APOB, APOL1 | CYP46A1 291/4885POLA1 1565/4885OSBP 1430/4885 |
| US-20220168379-A1 | LIPOPROTEIN TARGETING PROTEASE INHIBITORS AND USES | SERPINB1, APOB, APOL1 | CYP46A1 291/4885POLA1 1565/4885OSBP 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.