Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740779 | 0.79 | GAA (0.53) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14740016 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL24242362 | 0.69 | NPC1 (0.54) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14744636 | 0.67 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14740343 | 0.65 | GAA (0.51) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14739998 | 0.65 | GAA (0.51) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14740230 | 0.65 | GAA (0.51) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14740345 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL14740346 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9AKMT2ANPC1MAPT | |
| SCHEMBL22614998 | 0.63 | TUBB4A (0.57) | SMN1; SMN2RAB9AKMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |