Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276588 | 0.86 | HPGD (0.34) | HPGDGAALMNAALDH1A1KDM4E | |
| SCHEMBL30527359 | 0.85 | HPGD (0.41) | CYP3A4HPGDGAALMNAPOLB | |
| SCHEMBL10073228 | 0.82 | CYP3A4 (0.55) | CYP3A4ACHEHPGDLMNAPOLB | |
| SCHEMBL26078000 | 0.81 | CYP3A4 (0.39) | CYP3A4ACHELMNAALDH1A1KDM4E | |
| SCHEMBL23088256 | 0.79 | CYP3A4 (0.42) | CYP3A4ACHEHPGDGAALMNA | |
| SCHEMBL2019636 | 0.79 | HPGD (0.38) | CYP3A4HPGDGAALMNAPOLB | |
| SCHEMBL21932854 | 0.77 | HPGD (0.49) | CYP3A4HPGDGAALMNAALDH1A1 | |
| SCHEMBL17124306 | 0.77 | NOTUM (0.35) | HPGDLMNAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL1860753 | 0.75 | CYP3A4 (0.47) | CYP3A4ACHEHPGDLMNAPOLB | |
| SCHEMBL18298326 | 0.75 | CYP3A4 (0.47) | CYP3A4ACHEHPGDGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-03 | — | — | US | disclosed |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-11-17 | — | — | US | disclosed |
| US-11420940-B2 | 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-08-23 | — | — | US | disclosed |
| US-20200407314-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2020-12-31 | — | — | US | disclosed |
| US-10800739-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2020-10-13 | — | — | US | disclosed |
| EP-2912032-B1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2020-05-27 | — | — | EP | disclosed |
| US-20190330151-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2019-10-31 | — | — | US | disclosed |
| EP-2454236-B1 | 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2019-09-04 | — | — | EP | disclosed |
| US-10385018-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-08-20 | — | — | US | disclosed |
| US-20150274662-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-10-01 | — | — | US | disclosed |
| US-7968570-B2 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2011-06-28 | — | — | US | disclosed |
| US-7968570-B2 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2011-06-28 | — | — | US | disclosed |
| US-7968570-B2 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2011-06-28 | — | — | US | disclosed |
| WO-2011006794-A9 | 3-OXO-2, 3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-05 | — | — | WO | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP12 | CYP3A4 2769/4885ACHE 4072/4885HPGD 585/4885 |
| US-11420940-B2 | 4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors | PARP1, PARP2, PARP11 | CYP3A4 2263/4885ACHE 3980/4885HPGD 1019/4885 |
| US-20190330151-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | CYP3A4 2263/4885ACHE 3980/4885HPGD 1019/4885 |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM3 | CYP3A4 1095/4885ACHE 1263/4885HPGD 567/4885 |
| US-10800739-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP11 | CYP3A4 2263/4885ACHE 3980/4885HPGD 1019/4885 |
| US-10385018-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP11 | CYP3A4 2258/4885ACHE 3296/4885HPGD 313/4885 |
| US-20150274662-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | CYP3A4 2258/4885ACHE 3296/4885HPGD 313/4885 |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP12 | CYP3A4 2747/4885ACHE 4057/4885HPGD 574/4885 |
| US-20200407314-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | CYP3A4 2244/4885ACHE 3961/4885HPGD 997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.