Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26078000 | 0.88 | CYP3A4 (0.39) | NOTUMALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL17124307 | 0.82 | CYP3A4 (0.36) | ALDH1A1KDM4ESMN1; SMN2CES2CES1 | |
| SCHEMBL1862285 | 0.77 | CYP3A4 (0.44) | ALDH1A1LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21276588 | 0.76 | HPGD (0.34) | ALDH1A1LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12689499 | 0.73 | TSHR (0.47) | NOTUMALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL19779546 | 0.70 | PTGS1 (0.42) | KDM4ESMN1; SMN2DHODH | |
| SCHEMBL16481702 | 0.69 | TSHR (0.38) | KDM4ECYP11B1CYP11B2DHODH | |
| SCHEMBL20562679 | 0.69 | TSHR (0.38) | ALDH1A1CYP1A2CYP2C19KDM4ECYP11B1 | |
| SCHEMBL421459 | 0.68 | CYP3A4 (0.50) | NOTUMALDH1A1KDM4ESMN1; SMN2CES2 | |
| SCHEMBL30937561 | 0.66 | ALDH1A1 (0.36) | ALDH1A1LMNAKDM4EXDHHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274662-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274662-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP11 | NOTUM 4025/4885ALDH1A1 519/4885LMNA 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.