Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18625505 | 1.00 | MAPT (0.43) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL18625450 | 0.84 | MAPT (0.39) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL18625453 | 0.84 | MAPT (0.39) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL18625454 | 0.84 | MAPT (0.39) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL12500591 | 0.82 | NPC1 (0.40) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL12500589 | 0.82 | NPC1 (0.40) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL18625426 | 0.82 | MAPT (0.50) | MAPTSMN1; SMN2ALDH1A1EGLN1 | |
| SCHEMBL2158727 | 0.81 | MAPT (0.39) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL18644697 | 0.81 | MAPT (0.39) | MAPTCTSKNPC1RAB9AHTT | |
| SCHEMBL2158722 | 0.81 | MAPT (0.39) | MAPTCTSKNPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598419-B1 | Imidazotriazine and imidazodiazine compounds | UNIVERSITE DE MONTREAL (CA) | 2017-03-21 | — | — | US | disclosed |
| US-9598419-B1 | Imidazotriazine and imidazodiazine compounds | UNIVERSITE DE MONTREAL (CA) | 2017-03-21 | — | — | US | disclosed |
| US-9598419-B1 | Imidazotriazine and imidazodiazine compounds | UNIVERSITE DE MONTREAL (CA) | 2017-03-21 | — | — | US | disclosed |