Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158727 | 1.00 | MAPT (0.39) | MAPTNPC1RAB9AKMT2AHTT | |
| SCHEMBL2158722 | 1.00 | MAPT (0.39) | MAPTNPC1RAB9AKMT2AHTT | |
| SCHEMBL18625454 | 0.85 | MAPT (0.39) | MAPTNPC1RAB9AKMT2AHTT | |
| SCHEMBL18625450 | 0.85 | MAPT (0.39) | MAPTNPC1RAB9AKMT2AHTT | |
| SCHEMBL18625453 | 0.85 | MAPT (0.39) | MAPTNPC1RAB9AKMT2AHTT | |
| SCHEMBL18625504 | 0.81 | MAPT (0.43) | MAPTNPC1RAB9AKMT2AHTT | |
| SCHEMBL18625505 | 0.81 | MAPT (0.43) | MAPTNPC1RAB9AKMT2AHTT | |
| SCHEMBL18625414 | 0.80 | MAPT (0.46) | MAPTSMN1; SMN2ALDH1A1TRPA1KYAT1 | |
| SCHEMBL18625416 | 0.80 | MAPT (0.46) | MAPTSMN1; SMN2ALDH1A1TRPA1KYAT1 | |
| SCHEMBL14908440 | 0.80 | MAPT (0.64) | MAPTNPC1RAB9AKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598419-B1 | Imidazotriazine and imidazodiazine compounds | UNIVERSITE DE MONTREAL (CA) | 2017-03-21 | — | — | US | disclosed |
| US-9598419-B1 | Imidazotriazine and imidazodiazine compounds | UNIVERSITE DE MONTREAL (CA) | 2017-03-21 | — | — | US | disclosed |