Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15587402 | 0.83 | MAP4K4 (0.52) | MAP4K4ALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL18626531 | 0.83 | KDM4E (0.49) | MAP4K4ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18626473 | 0.81 | MAP4K4 (0.53) | MAP4K4ALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL17896318 | 0.80 | MAP4K4 (0.49) | MAP4K4ALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL18626501 | 0.79 | MAP4K4 (0.54) | MAP4K4ALDH1A1SMN1; SMN2 | |
| SCHEMBL17896303 | 0.79 | MAP4K4 (0.53) | MAP4K4MEN1KMT2ASIGMAR1ACHE | |
| SCHEMBL18626468 | 0.78 | HRH3 (0.51) | MAP4K4ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18626472 | 0.78 | MAP4K4 (0.47) | MAP4K4HRH3 | |
| SCHEMBL18626533 | 0.77 | MAP4K4 (0.50) | MAP4K4ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19008145 | 0.77 | MAP4K4 (0.52) | MAP4K4ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9592235-B2 | Aminoquinazoline and pyridopyrimidine derivatives | GENENTECH, INC. (US) | 2017-03-14 | — | — | US | disclosed |