Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15587421 | 0.85 | MAP4K4 (0.56) | MAP4K4GRM2DRD2DRD4MAOB | |
| SCHEMBL17896856 | 0.85 | MAP4K4 (0.56) | MAP4K4GRM2ALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL17896329 | 0.82 | MAP4K4 (0.54) | MAP4K4TSHRGRM2ALDH1A1DRD2 | |
| SCHEMBL18626467 | 0.79 | MAP4K4 (0.49) | MAP4K4ALDH1A1SMN1; SMN2 | |
| SCHEMBL18626504 | 0.75 | LMNA (0.46) | MAP4K4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL18626468 | 0.74 | HRH3 (0.51) | MAP4K4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL12359419 | 0.74 | AGTR2 (0.51) | MAP4K4ALDH1A1AGTR2 | |
| SCHEMBL19008143 | 0.74 | ALDH1A1 (0.49) | MAP4K4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL18626533 | 0.73 | MAP4K4 (0.50) | MAP4K4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL19008145 | 0.73 | MAP4K4 (0.52) | MAP4K4CYP2D6CYP2C9ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9592235-B2 | Aminoquinazoline and pyridopyrimidine derivatives | GENENTECH, INC. (US) | 2017-03-14 | — | — | US | disclosed |