Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12666701 | 0.91 | TRPV1 (0.42) | TRPV1MAOAKCNH2SCN9ASCN10A | |
| SCHEMBL1860029 | 0.89 | TRPV1 (0.59) | TRPV1SCN9AMAPK3 | |
| SCHEMBL1859967 | 0.86 | TRPV1 (0.59) | TRPV1MAOAKCNH2MAPK3LRRK2 | |
| SCHEMBL1858995 | 0.84 | TRPV1 (0.57) | TRPV1MAOAKCNH2MAPK3 | |
| SCHEMBL1862327 | 0.84 | TRPV1 (0.52) | TRPV1MAOAKCNH2SCN9AMAPK3 | |
| SCHEMBL12665825 | 0.82 | TRPV1 (0.48) | TRPV1MAOAKCNH2LRRK2 | |
| SCHEMBL1864958 | 0.80 | TRPV1 (0.66) | TRPV1MAOAKCNH2MAPK3 | |
| SCHEMBL1864049 | 0.80 | TRPV1 (0.46) | TRPV1SCN9ASCN10A | |
| SCHEMBL1870107 | 0.80 | TRPV1 (0.58) | TRPV1MAOAKCNH2MAPK3 | |
| SCHEMBL12666844 | 0.79 | TRPV1 (0.51) | TRPV1SCN9AMAPK3SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |