Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15090523 | 0.78 | EGFR (1.00) | EGFRERBB4KDRERBB2ERBB3 | |
| SCHEMBL18633116 | 0.73 | ERBB4 (0.57) | EGFRERBB4KDRERBB2ERBB3 | |
| Quinazoline SCHEMBL21924844 | 0.72 | EGFR (0.86) | EGFRERBB4KDRERBB2ERBB3 | |
| SCHEMBL15090691 | 0.72 | EGFR (1.00) | EGFRERBB4KDRERBB2ERBB3 | |
| Hydrochloric Acid SCHEMBL15090716 | 0.71 | EGFR (0.99) | EGFRERBB4KDRERBB2ERBB3 | |
| SCHEMBL15090516 | 0.71 | EGFR (0.86) | EGFRERBB4ERBB2SRCGAK | |
| SCHEMBL15105017 | 0.71 | EGFR (0.86) | EGFRERBB4ERBB2SRCGAK | |
| SCHEMBL15090569 | 0.70 | EGFR (0.84) | EGFRERBB4ERBB2SRCGAK | |
| SCHEMBL15090527 | 0.70 | EGFR (0.84) | EGFRERBB4ERBB2SRCGAK | |
| SCHEMBL15090487 | 0.70 | EGFR (0.81) | EGFRERBB4ERBB2ERBB3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |