Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18633730 | 0.86 | BRAF (0.46) | ABL1SRCMAPK14BRAF | |
| SCHEMBL2234459 | 0.84 | GBA1 (0.47) | GBA1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2234464 | 0.84 | GBA1 (0.47) | GBA1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2233369 | 0.84 | ABL1 (0.45) | GBA1MAPTABL1SRC | |
| SCHEMBL2233380 | 0.84 | ABL1 (0.45) | GBA1MAPTABL1SRC | |
| SCHEMBL14057434 | 0.75 | BRD4 (0.44) | GBA1MAPTMAPK14BRAF | |
| SCHEMBL2235668 | 0.75 | BRD4 (0.44) | GBA1MAPTMAPK14BRAF | |
| SCHEMBL2232164 | 0.72 | APP (0.40) | MAPTERBB2BRAF | |
| SCHEMBL2232159 | 0.72 | APP (0.40) | MAPTERBB2BRAF | |
| SCHEMBL2233664 | 0.72 | ABL1 (0.48) | ALDH1A1HPGDKDM4EMAPTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141552-A1 | THIENOPYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | Hanmi Pharm. Co., Ltd. (KR) | 2017-03-15 | — | — | EP | disclosed |