Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 7/20 | 0.44 |
| ▸ | SRC | P12931 | 7/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18633604 | 0.86 | GBA1 (0.43) | BRAFABL1SRCMAPK14 | |
| SCHEMBL2232226 | 0.84 | MAPK14 (0.46) | BRAFABL1SRCMAPK14 | |
| SCHEMBL2232232 | 0.84 | MAPK14 (0.46) | BRAFABL1SRCMAPK14 | |
| SCHEMBL2233672 | 0.83 | ABL1 (0.48) | BRAFABL1SRCRIPK2MAPK14 | |
| SCHEMBL2233664 | 0.83 | ABL1 (0.48) | BRAFABL1SRCRIPK2MAPK14 | |
| SCHEMBL2234230 | 0.77 | MAPT (0.45) | ABL1SRC | |
| SCHEMBL28039512 | 0.76 | MAPK14 (0.38) | BRAFABL1SRCRIPK2MAPK14 | |
| SCHEMBL2236177 | 0.76 | MAPK14 (0.46) | BRAFRIPK2MAPK14KITNPC1 | |
| SCHEMBL2236168 | 0.76 | MAPK14 (0.46) | BRAFRIPK2MAPK14KITNPC1 | |
| SCHEMBL12348401 | 0.75 | MAPK14 (0.40) | BRAFABL1SRCRIPK2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141552-A1 | THIENOPYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | Hanmi Pharm. Co., Ltd. (KR) | 2017-03-15 | — | — | EP | disclosed |