Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695552 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2CHRM3BCHEHSD11B1HRH3 | |
| SCHEMBL26442750 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2CHRM3BCHEHSD11B1HRH3 | |
| Hydrochloric Acid SCHEMBL2945460 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2CHRM3BCHEHSD11B1HRH3 | |
| SCHEMBL27675066 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2CHRM3BCHEHSD11B1HRH3 | |
| SCHEMBL16845009 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2CHRM3BCHEHSD11B1HRH3 | |
| SCHEMBL8439712 | 0.78 | BCHE (0.54) | SMN1; SMN2CHRM3BCHEHSD11B1HRH3 | |
| SCHEMBL26136665 | 0.77 | NAAA (0.60) | SMN1; SMN2CHRM3 | |
| Hydrochloric Acid SCHEMBL10970803 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2CHRM3BCHEHSD11B1KDM4E | |
| SCHEMBL26030610 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2CHRM3BCHEHSD11B1CHRM2 | |
| SCHEMBL23051072 | 0.75 | SCN1A (0.33) | CHRM3CHRM4CHRM5CHRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944625-B2 | Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-17 | — | — | US | disclosed |
| US-20170073330-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073330-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS | TFPI, TFPI2, KLKB1 | SMN1; SMN2 4813/4885CHRM3 4734/4885BCHE 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.