Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653940 | 0.81 | CCR1 (0.59) | CCR1CHRM2CCR5PARP1HTR2B | |
| SCHEMBL653939 | 0.81 | CCR1 (0.59) | CCR1CHRM2CCR5PARP1HTR2B | |
| SCHEMBL13616996 | 0.80 | CCR1 (0.55) | CCR1CHRM2CCR5HTR2B | |
| SCHEMBL16312654 | 0.79 | CCR1 (0.60) | CCR1CHRM2CCR5PARP1HRH1 | |
| SCHEMBL14420177 | 0.77 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL656051 | 0.77 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL656050 | 0.77 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL656376 | 0.76 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL656375 | 0.76 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL15478325 | 0.76 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1688418-B1 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARM INC (US) | 2017-03-15 | — | — | EP | disclosed |