Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17490338 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL17490349 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL16132385 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL17490360 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL16132477 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL16132483 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL16132485 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1CHRM3BLMAHR | |
| SCHEMBL16132387 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL16132352 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 | |
| SCHEMBL12238622 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CHRM3BLMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978759-B1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |