Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18635455 | 0.98 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL8018028 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL16132528 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL3122492 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL16132392 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL17490363 | 0.78 | L3MBTL1 (0.50) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL21742369 | 0.78 | NR1I2 (0.46) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL16132505 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| SCHEMBL16291257 | 0.76 | MEN1 (0.50) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 | |
| Hydrochloric Acid SCHEMBL11680499 | 0.76 | NPY2R (0.46) | SMN1; SMN2L3MBTL1MEN1KMT2ACHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978759-B1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |