Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453306 | 0.78 | PDE10A (0.47) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3501664 | 0.78 | PDE10A (0.52) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL1102411 | 0.78 | PDE10A (0.47) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL31300307 | 0.78 | PDE10A (0.47) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL8443010 | 0.78 | HTT (0.50) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL11870668 | 0.78 | PDE10A (0.47) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL27613092 | 0.76 | ALDH1A1 (0.39) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL25253725 | 0.75 | PDE10A (0.44) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL31707341 | 0.75 | SLC6A2 (0.48) | PDE10AHTTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL27917382 | 0.75 | SMN1; SMN2 (0.46) | PDE10AHTTHPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4101842-A1 | METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED AROMATIC HETEROCYCLIC COMPOUND | AGC INC. (JP) | 2022-12-14 | — | — | EP | disclosed |
| EP-2978759-B1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |