Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959260 | 0.87 | IRAK4 (0.38) | SOS1SCN9AIKBKBCHUKCA1 | |
| SCHEMBL1867175 | 0.81 | SOS1 (0.45) | SOS1CA1CA2CA9 | |
| Trifluoroacetic Acid SCHEMBL1700071 | 0.80 | IRAK4 (0.37) | SOS1SCN9ACA1CA2CA9 | |
| SCHEMBL1870366 | 0.79 | SCN9A (0.32) | SCN9A | |
| SCHEMBL29629045 | 0.76 | IKBKB (0.50) | SCN9AIKBKBCHUK | |
| SCHEMBL1700464 | 0.75 | SCN9A (0.37) | SCN9ACA1CA2CA9SCN5A | |
| SCHEMBL1700371 | 0.75 | BCL2 (0.37) | SCN9ACA1CA2CA9SCN5A | |
| SCHEMBL1700623 | 0.75 | SCN9A (0.39) | SCN9ACA1CA2CA9SCN5A | |
| SCHEMBL1700364 | 0.74 | SCN9A (0.33) | SCN9AIKBKBCHUK | |
| SCHEMBL1700543 | 0.74 | SCN9A (0.40) | SCN9ACA1CA2CA9SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138588-A9 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |