Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 9/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP10 | P09238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1700453 | 0.86 | SOS1 (0.46) | SOS1PTGS1PTGS2CA2CA1 | |
| SCHEMBL1867512 | 0.82 | SOS1 (0.36) | SOS1PTGS1PTGS2CA2CA1 | |
| SCHEMBL1863585 | 0.81 | SOS1 (0.35) | SOS1CA2CA1CA9 | |
| SCHEMBL1700536 | 0.74 | MEN1 (0.40) | SOS1PTGS1PTGS2CA2CA1 | |
| SCHEMBL30921523 | 0.74 | CA2 (0.43) | SOS1CA2CA1CA9CA12 | |
| SCHEMBL1700142 | 0.74 | CA2 (0.43) | SOS1CA2CA1CA9CA12 | |
| SCHEMBL1700537 | 0.72 | SOS1 (0.45) | SOS1PTGS1PTGS2CA2CA1 | |
| SCHEMBL1958517 | 0.70 | PTGS1 (0.36) | SOS1PTGS1PTGS2CA2CA1 | |
| SCHEMBL1957280 | 0.70 | PTGS1 (0.36) | SOS1PTGS1PTGS2CA2CA1 | |
| SCHEMBL1957281 | 0.70 | PTGS1 (0.36) | SOS1PTGS1PTGS2CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138588-A9 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |