Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ADA | P00813 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | PGK2 | P07205 | 1/20 | 0.39 |
| ▸ | MGMT | P16455 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18656236 | 0.88 | ADORA2A (0.46) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL9569382 | 0.86 | ADORA2A (0.49) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL15763449 | 0.86 | ADORA2A (0.54) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL14770011 | 0.86 | ADORA2A (0.65) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL721112 | 0.86 | ADORA2A (0.65) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL13468485 | 0.86 | ADORA2A (0.54) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL2499694 | 0.86 | ADORA2A (0.65) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL29722454 | 0.86 | ADORA2A (0.65) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL18656252 | 0.85 | ADORA2A (0.51) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 | |
| SCHEMBL13030120 | 0.85 | ADORA2A (0.51) | ADORA2AADORA3ADORA1ADORA2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755983-B1 | SUBSTITUTED CARBONYLOXYMETHYLPHOSPHORAMIDATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS | IDENIX PHARMACEUTICALS LLC (US) | 2017-03-15 | — | — | EP | disclosed |