SCHEMBL186365

SCHEMBL186365

Oc1ccc(C2=NCCO2)cc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
LTA4H P09960 1/20 0.42
ESR1 P03372 3/20 0.40
ESR2 Q92731 1/20 0.40
TYMP P19971 1/20 0.40
LSS P48449 1/20 0.39
MEN1 O00255 1/20 0.38
NPC1 O15118 1/20 0.38
USP2 O75604 1/20 0.38
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
PKM P14618 1/20 0.38
NFKB1 P19838 1/20 0.38
RAB9A P51151 1/20 0.38
NFKB2 Q00653 1/20 0.38
KMT2A Q03164 1/20 0.38
RELA Q04206 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9668585 0.98 KCNH2 (0.42) KCNH2HRH3LTA4HESR1ESR2
SCHEMBL132013 0.89 KCNH2 (0.49) KCNH2HRH3LTA4HLSSSMN1; SMN2
SCHEMBL9862901 0.88 KCNH2 (0.38) KCNH2HRH3LTA4HESR1ESR2
Hydrochloric Acid SCHEMBL9216279 0.86 KCNH2 (0.38) KCNH2HRH3LTA4HESR1ESR2
SCHEMBL20410837 0.81 KCNH2 (0.44) KCNH2HRH3LTA4HLSSSMN1; SMN2
SCHEMBL10520360 0.81 KCNH2 (0.48) KCNH2HRH3LTA4HLSSSMN1; SMN2
SCHEMBL9475161 0.81 KCNH2 (0.44) KCNH2HRH3LTA4HLSSSMN1; SMN2
SCHEMBL1856955 0.79 NPC1 (0.43) KCNH2HRH3LTA4HLSSMEN1
SCHEMBL20410952 0.79 KCNH2 (0.43) KCNH2HRH3LTA4HLSSSMN1; SMN2
SCHEMBL5464687 0.79 NPC1 (0.43) KCNH2HRH3LTA4HLSSNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115399332-A Oxazoline phenol inclusion compound, preparation method thereof and composition containing the inclusion compound 河北科技大学 2022-11-29 CN claimed
CN-106432568-B The preparation method of Yi Zhong Duo oxazolinyl chain extenders 福州大学 2018-10-30 CN claimed
CN-106905255-A Method for esterifying 2- (4, 5-dihydrooxazole) phenol compound by using microchannel reaction device 南京工业大学 2017-06-30 CN claimed
CN-106432568-A Preparation method of polyoxazolinyl chain extender 福州大学 2017-02-22 CN claimed
CN-101560192-B 2-oxazoline derivant and preparation method thereof UNIV BEIJING CHEMICAL 2015-04-29 CN claimed
CN-101560192-A 2-oxazoline derivant and preparation method thereof UNIV BEIJING CHEMICAL (CN) 2009-10-21 CN claimed
CN-1944429-A 2-oxazolinyl-benzo oxazinyl compound and its composition and preparing method BEIJING UNIV OF CHEMICAL TECHN (CN) 2007-04-11 CN claimed
US-5817430-A POLYARYLENEVINYLENE POLYMER XEROX CORPORATION (US) 1998-10-06 US claimed
EP-0137242-B1 (SUBSTITUTED) PHENYL-ALIPHATIC-ISOXAZOLES USEFUL AS ANTIVIRAL AGENTS AND PREPARATION THEREOF STERLING WINTHROP INC. (US) 1992-05-13 EP claimed
EP-0380807-A2 Reactive polycarbonates GENERAL ELECTRIC COMPANY (US) 1990-08-08 EP claimed
US-4940771-A Reactive polycarbonate end capped with hydroxy phenyl oxazoline GENERAL ELECTRIC COMPANY (US) 1990-07-10 US claimed
EP-0137242-A2 (Substituted) Phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof STERLING WINTHROP INC. (US) 1985-04-17 EP claimed
WO-2024263105-A1 A CURCUMIN COMPOSITION IN THE FORM OF MICELLES AND A METHOD OF PRODUCTION OF SAID COMPOSITION UNIVERZITA PAVLA JOZEFA SAFARIKA V KOSICIACH (SK) 2024-12-26 WO disclosed
CN-115399332-A Oxazoline phenol inclusion compound, preparation method thereof and composition containing the inclusion compound 河北科技大学 2022-11-29 CN disclosed
CN-115399332-A Oxazoline phenol inclusion compound, preparation method thereof and composition containing the inclusion compound 河北科技大学 2022-11-29 CN disclosed
CN-115399332-A Oxazoline phenol inclusion compound, preparation method thereof and composition containing the inclusion compound 河北科技大学 2022-11-29 CN disclosed
US-4851423-A Pharmaceutically active compounds SCHERING CORPORATION (US) 1989-07-25 US disclosed
US-4843087-A OXAZOLINYL COMPOUNDS; RHINOVIRUSES AND PICORNAVIRUSES STERLING DRUG INC. (US) 1989-06-27 US disclosed
EP-0274867-A2 Pharmaceutically active compounds SCHERING CORPORATION (US) 1988-07-20 EP disclosed
EP-0137242-A2 (Substituted) Phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof STERLING WINTHROP INC. (US) 1985-04-17 EP disclosed