Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 12/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.43 |
| ▸ | CDK2 | P24941 | 10/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15298054 | 1.00 | MAPK8 (0.52) | MAPK8MAPK10MAPK9CCND1CDK4 | |
| SCHEMBL18637767 | 0.89 | CCND1 (0.53) | MAPK8CCND1CDK4CCNE1CDK2 | |
| SCHEMBL22570031 | 0.88 | CCND1 (0.50) | MAPK8CCND1CDK4MAPK14CCNE1 | |
| SCHEMBL22570038 | 0.85 | MAPK1 (0.53) | MAPK8MAPK10MAPK9CCND1CDK4 | |
| SCHEMBL22570028 | 0.84 | CDK4 (0.52) | MAPK8MAPK10MAPK9CCND1CDK4 | |
| SCHEMBL17540002 | 0.82 | MAPK8 (0.52) | MAPK8MAPK10MAPK9CCND1MAPK14 | |
| SCHEMBL22570029 | 0.82 | CDK4 (0.47) | MAPK8MAPK10MAPK9CCND1CDK4 | |
| SCHEMBL19336266 | 0.81 | CDK4 (0.51) | CCND1CDK4CCNE1CDK2 | |
| SCHEMBL22570285 | 0.80 | CCND1 (0.45) | MAPK8CCND1CDK4CCNE1CDK2 | |
| SCHEMBL16074660 | 0.80 | MAPK8 (0.45) | MAPK8MAPK10MAPK9CCND1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216792-B1 | LACTAM KINASE INHIBITORS | G1 THERAPEUTICS INC (US) | 2020-05-27 | — | — | EP | disclosed |
| EP-2968290-B1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 THERAPEUTICS INC (US) | 2019-09-25 | — | — | EP | disclosed |
| EP-3216792-A1 | LACTAM KINASE INHIBITORS | Tavares, Francis Xavier (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2831080-B1 | LACTAM KINASE INHIBITORS | TAVARES FRANCIS XAVIER (US) | 2017-03-15 | — | — | EP | disclosed |